1.
Transfus Apher Sci
; 62(2): 103665, 2023 04.
Article
in English
| MEDLINE | ID: covidwho-2302620
2.
Transfus Apher Sci
; 60(4): 103174, 2021 Aug.
Article
in English
| MEDLINE | ID: covidwho-1251570
ABSTRACT
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is associated with high titers of immunoglobulin G class antibodies directed against the cationic platelet chemokine platelet factor 4 (PF4). These antibodies activate platelets via FcγIIa receptors. VITT closely resembles heparin-induced thrombocytopenia. Inflammation and tissue trauma substantially increase the risk for forming pathogenic PF4 antibodies. We therefore propose the use of therapeutic plasma exchange as rescue therapy in VITT to deplete antibodies plus factors promoting inflammation such as excess cytokines in the circulation as well as extracellular vesicles derived from activated platelets.
Subject(s)
COVID-19 Vaccines/adverse effects , Plasma Exchange , Platelet Factor 4/immunology , Purpura, Thrombotic Thrombocytopenic/therapy , Salvage Therapy , Albumins , Antibody Specificity , Anticoagulants , Autoantibodies/immunology , COVID-19 Vaccines/pharmacology , ChAdOx1 nCoV-19 , Citrates , Contraindications, Procedure , Cytokines/blood , Extracellular Vesicles , Humans , Immunoglobulin G/immunology , Immunosuppression Therapy , Inflammation , Plasma Exchange/adverse effects , Plasma Exchange/methods , Platelet Activation , Platelet Transfusion/adverse effects , Purpura, Thrombotic Thrombocytopenic/etiology , Purpura, Thrombotic Thrombocytopenic/immunology , Registries , Thrombocytopenia/etiology , Thrombosis/etiology
3.
Transfus Apher Sci
; 59(5): 102932, 2020 10.
Article
in English
| MEDLINE | ID: covidwho-1003100
4.
Transfus Apher Sci
; 59(4): 102854, 2020 08.
Article
in English
| MEDLINE | ID: covidwho-624171
Subject(s)
Betacoronavirus , Coronavirus Infections , Pandemics , Pneumonia, Viral , Blood Component Removal , COVID-19 , Coronavirus Infections/drug therapy , Coronavirus Infections/immunology , Coronavirus Infections/therapy , Cytokine Release Syndrome/prevention & control , Humans , Immunization, Passive , Pneumonia, Viral/immunology , Pneumonia, Viral/therapy , SARS-CoV-2 , COVID-19 Drug Treatment , COVID-19 Serotherapy
5.
Transfus Apher Sci
; 59(3): 102791, 2020 06.
Article
in English
| MEDLINE | ID: covidwho-200752